E87 Other disorders of fluid, electrolyte and acid-base balance Excludes1: diabetes insipidus (E23.2) electrolyte imbalance associated with hyperemesis gravidarum (O21.1) electrolyte imbalance following ectopic or molar pregnancy (O08.5) familial periodic paralysis (G72.3)
E87.0 Hyperosmolality and hypernatremia Sodium [Na] excess Sodium [Na] overload
Anhydration, anhydremia E86.0
– with
– – hypernatremia E87.0
– – hyponatremia E87.1
Anhydremia E86.0
– with
– – hypernatremia E87.0
– – hyponatremia E87.1
E87.1 Hypo-osmolality and hyponatremia Sodium [Na] deficiency Excludes1: syndrome of inappropriate secretion of antidiuretic hormone (E22.2)
E87.2 Acidosis Acidosis NOS Lactic acidosis Metabolic acidosis Respiratory acidosis Excludes1: diabetic acidosis – see categories E10-E13 with ketoacidosis
E87.3 Alkalosis Alkalosis NOS Metabolic alkalosis Respiratory alkalosis
E87.4 Mixed disorder of acid-base balance
E87.5 Hyperkalemia Potassium [K] excess Potassium [K] overload
E87.6 Hypokalemia Potassium [K] deficiency
E87.7 Fluid overload Excludes1: edema NOS (R60.-)
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified Electrolyte imbalance NOS Hyperchloremia Hypochloremia
E88 Other and unspecified metabolic disorders Use additional codes for associated conditions Excludes1: histiocytosis X (chronic) (C96.6)
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
Excludes1: disorder of lipoprotein metabolism (E78.-) monoclonal gammopathy (of undetermined significance) (D47.2)polyclonal hypergammaglobulinemia (D89.0) Waldenström macroglobulinemia (C88.0)
E88.01 Alpha-1-antitrypsin deficiency AAT deficiency
E88.09 Other disorders of plasma-protein metabolism, not elsewhere classified Bisalbuminemia
E88.1 Lipodystrophy, not elsewhere classified Lipodystrophy NOS Excludes1: Whipple’s disease (K90.81)
E88.2 Lipomatosis, not elsewhere classified Lipomatosis NOS Lipomatosis (Check) dolorosa [Dercum]
E88.3 Tumor lysis syndrome Tumor lysis syndrome (spontaneous) Tumor lysis syndrome following antineoplastic drug chemotherapy Code first (T45.1-) to identify drug, if drug induced
E88.4 Mitochondrial metabolism disorders
Excludes1: disorders of pyruvate metabolism (E74.4) Kearns-Sayre syndrome (H49.81) Leber’s disease (H47.22) Leigh’s encephalopathy (G31.82) Mitochondrial myopathy, NEC (G71.3) Reye’s syndrome (G93.7)
E88.40 Mitochondrial metabolism disorder, unspecified
E88.41 MELAS syndrome Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes
E88.42 MERRF syndrome Myoclonic epilepsy associated with ragged-red fibers Code also: myoclonic epilepsy (G40.3-)
E88.49 Other mitochondrial metabolism disorders
E88.8 Other specified metabolic disorders
E88.81 Metabolic syndrome Dysmetabolic syndrome X
E88.89 Other specified metabolic disorders Launois-Bensaude adenolipomatosis
E88.9 Metabolic disorder, unspecified
